Early prediction of IgA nephropathy progression: Proteinuria and AOPP are strong prognostic markers

Clinical course and prognostic factors of clinical early IgA nephropathy.

BACKGROUND Immunoglobulin A nephropathy (IgAN) is prevalent in many countries including China. At the time of diagnosis many IgAN patients present with normal renal function, proteinuria of 0.4 g/d or less, and normal blood pressure and they are classified as clinically early IgAN patients. However, the natural history of clinically early IgAN and prognostic factors has not yet been clarified. ...

Seasonal proteinuria changes in IgA nephropathy patients after proteinuria remission

BACKGROUND Proteinuria is a powerful prognostic factor for end-stage renal disease in IgA nephropathy (IgAN) patients. However, it is not known whether proteinuria exacerbations are related to seasonal changes. METHODS We retrospectively enrolled consecutive patients diagnosed with IgAN by kidney biopsy at our hospital between 2002 and 2014. Proteinuria remission was defined as urinary protei...

Slowing nephropathy progression: focus on proteinuria reduction.

Blood pressure control reduces decline of kidney function. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers offer renoprotection to a small extent beyond that attributable to blood pressure lowering. These agents also reduce proteinuria, a risk marker for renal disease progression. Accumulating evidence indicates that their antiproteinuric effect correlates with their ...

IgA Nephropathy and Significance of Immunostaining Data

Optimal Proteinuria Target for Renoprotection in Patients with IgA Nephropathy

BACKGROUND Proteinuria is a target for renoprotection in kidney diseases. However, optimal level of proteinuria reduction in IgA nephropathy (IgAN) is unknown. METHODS We conducted a retrospective observational study in 500 patients with biopsy-proven IgAN. Time-averaged proteinuria (TA-P) was calculated as the mean of every 6 month period of measurements of spot urine protein-to-creatinine r...